Regulation of connective tissue growth factor (ccn2; ctgf) gene expression in human mesangial cells: modulation by HMG CoA reductase inhibitors (statins)

DOI to cite this document:: 10.5283/epub.1264

Goppelt-Struebe, M. ; Hahn, A. ; Iwanciw, D. ; Rehm, M. ; Banas, B.

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Date of publication of this fulltext: 05 Aug 2009 13:26

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Abstract

AIM: Connective tissue growth factor (ccn; ctgf) gene expression is upregulated in fibrotic renal glomeruli. Therefore, the regulation and pharmacological modulation of ccn2 (ctgf) mRNA expression was investigated in a human renal mesangial cell line. METHODS: A human renal mesangial cell line was cultured in vitro under standard conditions. After stimulation, RNA was extracted and ccn2 (ctgf) ...