N-acetylcysteine in the prevention of radiocontrast-induced nephropathy: clinical trials and end points

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1285

Hoffmann, Ute ; Banas, Bernhard ; Fischereder, Michael ; Krämer, Bernhard K.

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:27

Alternative Links zum Volltext:DOI Pubmed Verlag

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Zusammenfassung

N-acetylcysteine (NAC) has been suggested to prevent radiocontrast-induced nephropathy (RCIN) in patients with a reduced renal function. However, clinical studies have not been demonstrating this effect consistently. Also, reviews and meta-analyses dealing with the question of prevention of RCIN by NAC have been controversial. Nearly all investigators used serum creatinine as surrogate end point ...