Localization and functional characterization of glycosaminoglycan domains in the normal human kidney as revealed by phage display-derived single chain antibodies

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1300

Lensen, Joost F. M. ; Rops, Angelique L. W. M. M. ; Wijnhoven, Tessa J. M. ; Hafmans, Theo ; Feitz, Wouter F. J. ; Oosterwijk, Egbert ; Banas, Bernhard ; Bindels, René J. M. ; van den Heuvel, Lambert P. W. J. ; van der Vlag, Johan ; Berden, Jo H. M. ; van Kuppevelt, Toin H.

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:27

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Zusammenfassung

Glycosaminoglycans (GAG) play an important role in renal homeostasis. They are strongly negatively charged polysaccharides that bind and modulate a myriad of proteins, including growth factors, cytokines, and enzymes. With the aid of specific phage display-derived antibodies, the distribution of heparan sulfate (HS) and chondroitin sulfate (CS) domains in the normal human kidney was studied. HS ...