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Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts

Kühnle, Matthias (2010) Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts. PhD, Universität Regensburg.

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Date of publication of this fulltext: 09 Mar 2010 08:59

Abstract (English)

The treatment of malignant brain tumors, especially of high-grade gliomas, poses one of the major challenges in cancer therapy. Despite seminal advancements in imaging techniques for the early diagnosis of CNS neoplasms as well as amendments in surgery and radiooncology, the prognosis of patients with glioma is very poor. The administration of temozolomide adjuvant to irradiation after resection ...

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Translation of the abstract (German)

Die Behandlung maligner Hirntumoren, insbesondere hochgradiger Gliome, ist eine der größten Herausforderungen der Krebstherapie. Trotz erheblicher Weiterentwicklung der Bildgebungsverfahren zur frühen Diagnose von ZNS Tumoren und Verbesserungen chirurgischer sowie insbesondere strahlentherapeutischer Techniken ist die Prognose betroffener Patienten äußerst schlecht. Mit Temozolomid als Adjuvans ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:9 March 2010
Referee:Prof. Dr. Armin Buschauer and Prof. Dr. Günther Bernhardt
Date of exam:16 February 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:glioblastoma, nanoparticles, ABCG2, optical imaging, xenografts Glioblastom, Nanopartikel, ABCG2, Optisches Imaging, Xenotransplantate
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13008
Owner only: item control page

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