Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1308

de Lema, Guillermo Pérez ; Maier, Holger ; Franz, Tobias J. ; Escribese, Maríia ; Chilla, Silvia ; Segerer, Stephan ; Camarasa, Natalia ; Schmid, Holger ; Banas, Bernhard ; Kalaydjiev, Svetoslav ; Busch, Dirk H. ; Pfeffer, Klaus ; Mampaso, Francisco ; Schlöndorff, Detlef ; Luckow, Bruno

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:27

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MRL/MpJ-Fas(lpr)/J (MRL/lpr) mice represent a well-established mouse model of human systemic lupus erythematosus. MRL/lpr mice homozygous for the spontaneous lymphoproliferation mutation (lpr) are characterized by systemic autoimmunity, massive lymphadenopathy associated with proliferation of aberrant T cells, splenomegaly, hypergammaglobulinemia, arthritis, and fatal immune complex-mediated ...