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Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin

URN to cite this document:
urn:nbn:de:bvb:355-opus-14117
Mohammed, Hesham Hamada Taha
Date of publication of this fulltext: 24 Feb 2010 09:16


Abstract (English)

Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional antibiotic treatment is ineffective against either toxemia or antibiotic- resistant strains. Thus, more effective drugs for anthrax treatment ...

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Translation of the abstract (German)

Bacillus anthracis verursacht Milzbrand Krankheit und übt seine schädlichen Auswirkungen durch die Freisetzung von drei Exotoxinen aus, Lethal Faktor, Protective Antigen und Edema Faktor (EF), eine sehr aktive CaM-abhängige Adenylylcyclase (AC). Eine konventionelle antibiotische Behandlung ist jedoch unwirksam entweder aufgrund toxemia oder Antibiotikum- Resistenzen. Somit sind wirksamere ...

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