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Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin

Mohammed, Hesham Hamada Taha (2010) Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin. PhD, Universität Regensburg.

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Date of publication of this fulltext: 24 Feb 2010 09:16

Abstract (English)

Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional antibiotic treatment is ineffective against either toxemia or antibiotic- resistant strains. Thus, more effective drugs for anthrax treatment ...

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Translation of the abstract (German)

Bacillus anthracis verursacht Milzbrand Krankheit und übt seine schädlichen Auswirkungen durch die Freisetzung von drei Exotoxinen aus, Lethal Faktor, Protective Antigen und Edema Faktor (EF), eine sehr aktive CaM-abhängige Adenylylcyclase (AC). Eine konventionelle antibiotische Behandlung ist jedoch unwirksam entweder aufgrund toxemia oder Antibiotikum- Resistenzen. Somit sind wirksamere ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:7 January 2010
Referee:Roland (Prof. Dr.) Seifert
Date of exam:26 November 2009
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Keywords:Cyclonucleotide , Sekundärer Bote , Adenylatcyclase , Bakterien , Toxin , Exotoxin , Bacillus anthracis , Adenylylcyclase , bakterielle Adenylylcyclase-Toxine , Ödemefaktor , adenylyl cyclase , bacterial adenylyl cyclase toxins , edema factor
Dewey Decimal Classification:500 Science
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13096
Owner only: item control page

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