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Quantitative and functional analysis of chromosome dynamics: Influence of the nucleolus on the regulation of gene expression

Berger, Axel B. (2010) Quantitative and functional analysis of chromosome dynamics: Influence of the nucleolus on the regulation of gene expression. PhD, Universität Regensburg.

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Date of publication of this fulltext: 24 Feb 2010 09:17

Abstract (English)

Chromatin is distributed non-randomly within the cell nucleus. Its spatial organization has been demonstrated to be important for nuclear metabolism such as, DNA replication, reparation or transcription. However, little is known about the functional implications resulting from its organization or the molecular driving forces responsible for chromatin organization. In the course of this thesis, I ...


Translation of the abstract (German)

Im Zellkern liegt die in Chromatin verpackte DNA nicht zufällig verteilt vor. Es wurde gezeigt, dass die räumliche Lokalisation von Chromatin einen wichtigen Einfluß auf nukleäre Prozesse wie DNA Replikation, Reparatur oder Transkription hat. Bisher gibt es jedoch nur wenige Hinweise auf die funktionellen Auswirkungen dieser Organisation sowie auf die molekularen Kräfte, die für die ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:18 February 2010
Referee:Herbert (Prof. Dr.) Tschochner
Date of exam:11 December 2008
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Herbert Tschochner
Keywords:Saccharomyces cerevisiae , Nucleolus , RNS-Polymerase I , Genexpression , Zellkern , Chromatin , Ribosomenproteine , Ribosomale DNS , Ribosomale Proteine , Genlokalisierung , Hmo1 , Saccharomyces cerevisiae , Hmo1 , Pol I , Ribosomal protein genes , Nuclear architecture
Dewey Decimal Classification:500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13102
Owner only: item control page


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