Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1311

Wörnle, Markus ; Schmid, Holger ; Banas, Bernhard ; Merkle, Monika ; Henger, Anna ; Roeder, Maximilian ; Blattner, Simone ; Bock, Elisabeth ; Kretzler, Matthias ; Gröne, Hermann-Josef ; Schlöndorff, Detlef

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:27

Alternative Links zum Volltext:Pubmed Verlag

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Hepatitis C virus (HCV) infection is frequently complicated by glomerulonephritis with immune complexes containing viral RNA. We examined the potential influence of Toll-like receptors (TLRs), specifically TLR3 recognition of viral dsRNA exemplified by polyriboinosinic:polyribocytidylic acid [poly(I:C) RNA]. Normal human kidney stained positive for TLR3 on mesangial cells (MCs), vascular smooth ...