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Studies towards synthesis of biologically active guaianolides: enantioselective total synthesis of (+)-Arglabin

Kalidindi, Srinivas (2010) Studies towards synthesis of biologically active guaianolides: enantioselective total synthesis of (+)-Arglabin. PhD, Universität Regensburg.

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Date of publication of this fulltext: 19 Jul 2010 10:09

Abstract (English)

Guaianolides consisting of tricyclic 5,7,5-ring system represents one of the largest subgroup of naturally occurring sesquiterpene lactones[1]. Along with the structural diversity guaianolides exhibits a broad range of biological activity and stimulates the development of research in their total synthesis. (+)-Arglabin, a prominent member of guaianolides was isolated from Artemisia glabella [2a] ...


Translation of the abstract (German)

Guaianolide setzen sich aus einem 5,7,5-Ringsystem zusammen, das eine der verbreitetsten Untergruppen der natürlich vorkommenden Sesquiterpenlaktone repräsentiert [1]. Neben ihrer strukturellen Diversität weisen Guaianolide breite biologische Aktivität auf, was einen zusätzlichen Anreiz für deren Totalsynthese gibt. (+)-Arglabin, ein weit verbreitetes Mitglied der Guaianolid-FamilIe wurde aus ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:19 July 2010
Referee:Prof. Dr. Oliver Reiser
Date of exam:22 June 2009
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Interdisciplinary Subject Network:Not selected
Keywords:Arglabin, asymmetrische Synthese, Franesyl-Transferase, Naturstoffe, Totalsynthese, Arglabin, asymmetric synthesis, farnesyl transferase, natural products, total synthesis
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13412
Owner only: item control page


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