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Layer-by-layer assembled gold nanoparticles for siRNA delivery

Elbakry, Asmaa ; Zaky, Alaa ; Liebl, Renate ; Rachel, Reinhard ; Goepferich, Achim ; Breunig, Miriam



Abstract

Although uptake into cells is highly complex and regulated, heterogeneous particle collectives are usually employed to deliver small interfering RNA (siRNA) to cells. Within these collectives, it is difficult to accurately identify the active species, and a decrease in efficacy is inherent to such preparations. Here, we demonstrate the manufacture of uniform nanoparticles with the deposition of ...

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