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Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex.

Douangamath, Alice ; Walker, Martina ; Beismann-Driemeyer, Silke ; Vega-Fernandez, M. Cristina ; Sterner, Reinhard ; Wilmanns, Matthias


Since reactive ammonia is not available under physiological conditions, glutamine is used as a source for the incorporation of nitrogen in a number of metabolic pathway intermediates. The heterodimeric ImGP synthase that links histidine and purine biosynthesis belongs to the family of glutamine amidotransferases in which the glutaminase activity is coupled with a subsequent synthase activity ...


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