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A histidine gene cluster of the hyperthermophile Thermotoga maritima: sequence analysis and evolutionary significance.

Thoma, Ralf ; Schwander, M. ; Liebl, W. ; Kirschner, Kasper ; Sterner, Reinhard



Abstract

The sequences of histidine operon genes in hyperthermophiles are informative for understanding high protein thermostability and the evolution of metabolic pathways. Therefore, a cluster of eight his genes from the hyperthermophilic and phylogenetically early bacterium Thermotoga maritima was cloned and sequenced. The cluster has the gene order hisDCBdHAFI-E, lacking only hisG and hisBp, and does ...

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