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Molecular and cellular analysis of the "adenylyl cyclase" exotoxins from Bacillus anthracis and Bordetella pertussis

Spangler, Corinna (2010) Molecular and cellular analysis of the "adenylyl cyclase" exotoxins from Bacillus anthracis and Bordetella pertussis. PhD, Universität Regensburg.

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Date of publication of this fulltext: 26 Jul 2010 10:19

Abstract (English)

The adenylyl cyclase (AC) toxins EF and CyaA contribute to the pathogenity and mortality of anthrax and whooping cough caused by Bacillus anthracis and Bordetella pertussis, respectively. Inhibitors of bacterial toxins would mitigate the course of disease and increase survival rates. A luminescence-based AC assay was developed as screening tool for AC toxin inhibitors. The assay prooved to be ...


Translation of the abstract (German)

Die Adenylyl-Zyklase-(AC)-Toxine EF und CyaA tragen zur Pathogenität und Mortalität von Anthrax und Keuchhusten bei. Inhibitoren, die auf bakterielle Toxinen wirken, würden deshalb den Verlauf der Krankheit mildern und die Überlebenschancen erhöhen können. Ein lumineszenzbasierter AC-Assay wurde für das Screening von Inhibitoren für AC-Toxine entwickelt. Der Assay hat sich als schnell und ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:26 July 2010
Referee:Prof. Dr. Roland Seifert and Prof. Dr. Otto Wolfbeis
Date of exam:11 June 2010
Institutions:Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Interdisciplinary Subject Network:Not selected
Keywords:adenylyl cyclases, toxins, edema factor, Bacillus anthracis, Bordetella pertussis, cyclic nucleotides
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:14085
Owner only: item control page


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