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Destruction of human solid tumors by alkyl lysophospholipids

Runge, M. H. ; Andreesen, Reinhard ; Pfleiderer, A. ; Munder, P. G.


Alkyl lysophospholipids (ALP) are synthetic analogs of the naturally occurring 2-lysophosphatidylcholine. The effect of ALP on the proliferation of 22 different gynecologic malignant tumors in humans was studied in vitro. ALP caused progressive death of tumor cells over 24-96 hours. In addition, tumor specimens from the tested human tumors were xenotransplanted into NMRI nude mice. ALP induced a ...


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