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Temperature dependence of leukemic cell destruction by alkyl-lysophospholipids (NSC 324368)

Andreesen, Reinhard ; Modolell, M. ; Oepke, G. H. ; Munder, P. G.


Alkyl-analogs (ALP) of 2-lysophosphatidylcholine induce a progressive destruction of neoplastic cells by interfering with the continuous turnover of membrane phospholipids. Using leukemic blast cells from patients with acute forms of leukemia the effect of temperature was evaluated. It was found that temperature strongly influences the cytotoxic activity of ALP. High temperatures potentiate ...


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