Andreesen, Reinhard ; Osterholz, J. ; Luckenbach, G. A. ; Costabel, U. ; Schulz, A. ; Speth, V. ; Munder, P. G. ; Löhr, G. W.
Alternative Links zum Volltext:Pubmed
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Journal of the National Cancer Institute |
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| Band: | 72 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 |
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| Seitenbereich: | S. 53-9 |
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| Datum: | 1984 |
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| Institutionen: | Medizin > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
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| Identifikationsnummer: | |
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| Klassifikation: | | Notation | Art |
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| Antineoplastic Agents/pharmacology | MESH | | Cell Line | MESH | | Cytotoxicity, Immunologic | MESH | | Humans | MESH | | Lymphoma/immunology | MESH | | Lysophosphatidylcholines | MESH | | Macrophage Activation/drug effects | MESH | | Macrophages/immunology | MESH | | Phospholipid Ethers/pharmacology | MESH | | Platelet Activating Factor/pharmacology | MESH |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 14194 |
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Zusammenfassung
Human alveolar macrophages as well as macrophages derived from Teflon culture of blood-borne monocytes were incubated with synthetic analogues of 2-lysophosphatidylcholine and then tested for their cytotoxic capacity against an allogeneic lymphoma cell line. Metabolic, rather stable analogues enhanced macrophage cytotoxicity significantly. This phenomenon was shown both in a growth-inhibition ...
Zusammenfassung
Human alveolar macrophages as well as macrophages derived from Teflon culture of blood-borne monocytes were incubated with synthetic analogues of 2-lysophosphatidylcholine and then tested for their cytotoxic capacity against an allogeneic lymphoma cell line. Metabolic, rather stable analogues enhanced macrophage cytotoxicity significantly. This phenomenon was shown both in a growth-inhibition assay as well as in the 51Cr release assay. Macrophage activation was dose- and time-dependent and was potentiated at temperatures above 37 degrees C. Incubation of the macrophages with the active compounds induced characteristic changes in cell morphology as revealed by scanning electron microscopy.
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