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Tumor cytotoxicity of human macrophages after incubation with synthetic analogues of 2-lysophosphatidylcholine

Andreesen, Reinhard ; Osterholz, J. ; Luckenbach, G. A. ; Costabel, U. ; Schulz, A. ; Speth, V. ; Munder, P. G. ; Löhr, G. W.


Human alveolar macrophages as well as macrophages derived from Teflon culture of blood-borne monocytes were incubated with synthetic analogues of 2-lysophosphatidylcholine and then tested for their cytotoxic capacity against an allogeneic lymphoma cell line. Metabolic, rather stable analogues enhanced macrophage cytotoxicity significantly. This phenomenon was shown both in a growth-inhibition ...


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