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Defective monocyte-to-macrophage maturation in patients with aplastic anemia

Andreesen, Reinhard ; Brugger, W. ; Thomssen, C. ; Rehm, A. ; Speck, B. ; Löhr, G. W.


Macrophages (MAC) are important effector cells of the immune system but also play an essential role as regulatory cells in hematopoiesis. They originate from circulating monocytes (MO) as immature precursor cells that undergo terminal differentiation upon migration from the capillary bed into the various tissues. In the presence of serum, MAC maturation from blood MO is observed in vitro and can ...


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