Monocyte differentiation and accessory function: different effects on the proliferative responses of an autoreactive T cell clone as compared to alloreactive or antigen-specific T cell lines and primary mixed lymphocyte cultures

URN zum Zitieren dieses Dokuments:

urn:nbn:de:bvb:355-epub-142861 Copy

DOI zum Zitieren dieses Dokuments:

10.5283/epub.14286 Copy

Schlesier, M. ; Krause, S. ; Dräger, R. ; Wolff-Vorbeck, G. ; Kreutz, Marina ; Andreesen, Reinhard ; Peter, H. H.

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Veröffentlichungsdatum dieses Volltextes: 14 Apr 2010 05:10

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Alternative Links zum Volltext:Pubmed

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Details

Dokumentenart:	Artikel
Titel eines Journals oder einer Zeitschrift:	Immunobiology
Verlag:	Elsevier
Band:	190
Nummer des Zeitschriftenheftes oder des Kapitels:	1-2
Seitenbereich:	S. 164-174
Datum:	1994
Institutionen:	Medizin > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identifikationsnummer:	Wert Typ 7521857 PubMed-ID
Klassifikation:	Notation Art Antigen-Presenting Cells/immunology MESH Antigens, Surface/biosynthesis MESH Autoantigens/immunology MESH Cell Differentiation/physiology MESH Cell Division/immunology MESH Cell Line MESH Epitopes/immunology MESH Humans MESH Isoantigens/immunology MESH Lymphocyte Activation/immunology MESH Lymphocyte Culture Test, Mixed MESH Monocytes/immunology MESH T-Lymphocyte Subsets/immunology MESH
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Ja
Dokumenten-ID:	14286

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Zusammenfassung

An autoreactive T cell clone derived from a patient with reactive arthritis, two alloreactive T cell lines, two antigen-specific T cell lines and allogeneic resting T cells were analyzed for their responses to monocytes and macrophages derived from monocytes by in vitro differentiation. The autoreactive T cell clone strongly proliferated in response to fresh monocytes and to macrophages derived ...

Zusammenfassung

An autoreactive T cell clone derived from a patient with reactive arthritis, two alloreactive T cell lines, two antigen-specific T cell lines and allogeneic resting T cells were analyzed for their responses to monocytes and macrophages derived from monocytes by in vitro differentiation. The autoreactive T cell clone strongly proliferated in response to fresh monocytes and to macrophages derived from a 7 day culture, but only poorly to monocytes cultured for 2 days. In contrast, alloreactive and antigen-specific T cell lines proliferated to all stimulatory cells equally well. Finally, primary mixed lymphocyte reactions could be stimulated by both fresh and 2-day cultured monocytes, but not by in vitro derived macrophages. The impaired response of the autoreactive T cell clone to 2-day cultured monocytes could not be attributed to reduced expression of several well-defined surface molecules nor to induction of nonresponsiveness. Neither allogeneic monocytes nor cytokines (IL-1, IL-2, IL-4, IL-6) could correct the defective response of the autoreactive T cell clone. However, preculture of monocytes in the presence of interferon-gamma, IL-1, IL-4 or IL-6 retained their stimulatory capacity. Our interpretation of the selectively impaired response of the autoreactive T cell clone is that it most likely recognizes a differentiation-dependent monocyte/macrophage-specific peptide.

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