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Three-dimensional co-culture of human monocytes and macrophages with tumor cells: analysis of macrophage differentiation and activation

Konur, A. ; Kreutz, M. ; Knüchel, R. ; Krause, S. W. ; Andreesen, Reinhard



Abstract

Here we report on an experimental system for generating TAM in vitro by culturing human MO and MO-derived macrophages (MAC) within 3-dimensional multicellular tumor spheroids (MCS). MO as well as MO-derived MAC migrate into tumor spheroids and spread throughout the entire spheroid within 16 hr. In contrast, fibroblast-spheroids were not infiltrated. The regular expression of MAC ...

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