Fingerle-Rowson, G., Angstwurm, M., Andreesen, Reinhard and Ziegler-Heitbrock, H. W.
(1998)
Selective depletion of CD14+ CD16+ monocytes by glucocorticoid therapy.
Clinical and experimental immunology 112 (3), pp. 501-6.
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at PubMed
Abstract
Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on many cells of the body, including monocytes. Here we show that a 5-day course of high dose GC therapy differentially affected the CD14++ and the CD14+ CD16+ monocyte subpopulations in 10 patients treated for multiple sclerosis. While the classical (CD14++) monocytes exhibited a substantial increase from 495 ...
Abstract
Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on many cells of the body, including monocytes. Here we show that a 5-day course of high dose GC therapy differentially affected the CD14++ and the CD14+ CD16+ monocyte subpopulations in 10 patients treated for multiple sclerosis. While the classical (CD14++) monocytes exhibited a substantial increase from 495 +/- 132 to 755 +/- 337 cells/microl, the CD14+ CD16+ monocytes responded with a pronounced decrease from 36 +/- 15 to 2 +/- 3 cells/microl (P < 0.001). In 4/10 patients the CD14+ CD16+ monocytes fell below detection limits (<0.2 cells/microl). This observation was confirmed when the CD14+ CD16+ monocytes were identified by virtue of their low CD33 expression as these cells decreased as well. After discontinuation of GC therapy the CD14+ CD16+ monocytes reappeared and reached normal levels after 1 week. The profound depletion of CD14+ CD16+ monocytes by GC as described here is a novel effect of GC action in vivo and may contribute to GC-mediated immunosuppression. Determination of the number of this monocyte subset may also serve to monitor the effectiveness of GC therapy in patients requiring immunosuppressive treatment.
Export bibliographical data
| Item type: | Article |
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| Date: | 1998 |
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| Institutions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
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| Identification Number: | | Value | Type |
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| 2478233 | PubMed ID |
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| Classification: | | Notation | Type |
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| Adult | MESH | | Antigens, CD14/immunology | MESH | | Female | MESH | | Flow Cytometry | MESH | | Glucocorticoids/administration & dosage | MESH | | Humans | MESH | | Immunosuppression | MESH | | Immunosuppressive Agents/administration & dosage | MESH | | Injections, Intravenous | MESH | | Male | MESH | | Middle Aged | MESH | | Monocytes/immunology | MESH | | Multiple Sclerosis/immunology | MESH | | Receptors, IgG/immunology | MESH |
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| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine |
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| Status: | Published |
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| Refereed: | Yes, this version has been refereed |
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| Created at the University of Regensburg: | Yes |
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| Item ID: | 14331 |
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