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Selective depletion of CD14+ CD16+ monocytes by glucocorticoid therapy

Fingerle-Rowson, G. ; Angstwurm, M. ; Andreesen, Reinhard ; Ziegler-Heitbrock, H. W.



Abstract

Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on many cells of the body, including monocytes. Here we show that a 5-day course of high dose GC therapy differentially affected the CD14++ and the CD14+ CD16+ monocyte subpopulations in 10 patients treated for multiple sclerosis. While the classical (CD14++) monocytes exhibited a substantial increase from 495 ...

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