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Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages

Holtrich, U. ; Wolf, G. ; Yuan, J. ; Bereiter-Hahn, J. ; Karn, T. ; Weiler, M. ; Kauselmann, G. ; Rehli, M. ; Andreesen, Reinhard ; Kaufmann, M. ; Kuhl, D. ; Strebhardt, K.



Abstract

Members of the polo subfamily of protein kinases play crucial roles in cell proliferation. To study the function of this family in more detail, we isolated the cDNA of human Fnk (FGF-inducible kinase) which codes for a serine/threonine kinase of 646 aa. Despite the homology to the proliferation-associated polo-like kinase (Plk), tissue distribution of Fnk transcripts and expression kinetics ...

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