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Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide

Eissner, Günther ; Multhoff, Gabriele ; Gerbitz, Armin ; Kirchner, Silvia ; Bauer, Sonja ; Haffner, Silvia ; Sondermann, Daniela ; Andreesen, Reinhard ; Holler, Ernst


Fludarabine is a nonmyeloablative immunosuppressant increasingly used as a component of alternative conditioning regimens before allogeneic bone marrow transplantation. It is expected to reduce conditioning-related toxicity and proinflammatory activation of the host tissues. However, in our in vitro study, we provide evidence that 2-fluoroadenine 9-beta-D-arabinofuranoside (F-Ara) as the active ...


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