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The treatment of patients with disseminated malignant melanoma by vaccination with autologous cell hybrids of tumor cells and dendritic cells

Krause, Stefan W ; Neumann, Christine ; Soruri, Afasaneh ; Mayer, Stephanie ; Peters, J. Hinrich ; Andreesen, Reinhard



Abstract

Malignant melanoma has been shown to be susceptible to T cell-mediated immunity and, therefore, is a candidate for vaccination approaches. Clinical trials using dendritic cells (DC) loaded with peptides corresponding to tumor antigens are ongoing in several institutions, and some promising results have already been published. However, every single peptide-based vaccine can only be used in a ...

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