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Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells

Fritsche, Jana ; Mondal, Krishna ; Ehrnsperger, Achim ; Andreesen, Reinhard ; Kreutz, Marina



Zusammenfassung

25-Hydroxyvitamin D-3-1alpha-hydroxylase (25(OH)D-3-1alpha-hydroxylase), the key enzyme of 1alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) production, is expressed in monocyte-derived macrophages (MACs). Here we show for the first time constitutive expression of 25(OH)D-3-1alpha-hydroxylase in monocyte-derived dendritic cells (DCs), which was increased after stimulation with lipopolysaccharide ...

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