| Dokumentenart: | Artikel | ||||||||||||||||||||||||||||||||||||||
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| Titel eines Journals oder einer Zeitschrift: | Cancer | ||||||||||||||||||||||||||||||||||||||
| Verlag: | JOHN WILEY & SONS INC | ||||||||||||||||||||||||||||||||||||||
| Ort der Veröffentlichung: | HOBOKEN | ||||||||||||||||||||||||||||||||||||||
| Band: | 98 | ||||||||||||||||||||||||||||||||||||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 10 | ||||||||||||||||||||||||||||||||||||||
| Seitenbereich: | S. 2251-6 | ||||||||||||||||||||||||||||||||||||||
| Datum: | 2003 | ||||||||||||||||||||||||||||||||||||||
| Institutionen: | Medizin > Lehrstuhl für Dermatologie und Venerologie Medizin > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medizin > Lehrstuhl für Pathologie | ||||||||||||||||||||||||||||||||||||||
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| Stichwörter / Keywords: | SOFT-TISSUE SARCOMA; ORAL TROFOSFAMIDE; PPAR-GAMMA; PRETREATED PATIENTS; PHASE-II; ANGIOSARCOMA; CANCER; ANGIOGENESIS; CHEMOTHERAPY; DOXORUBICIN; malignant vascular tumor; angiosarcoma; antiangiogenetic; palliative treatment; biomodulating drugs | ||||||||||||||||||||||||||||||||||||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||||||||||||||||||||||||||||||||||||
| Status: | Veröffentlicht | ||||||||||||||||||||||||||||||||||||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||||||||||||||||||||||||||||||||||||
| An der Universität Regensburg entstanden: | Ja | ||||||||||||||||||||||||||||||||||||||
| Dokumenten-ID: | 14424 |
Web of ScienceZusammenfassung
BACKGROUND. Systemic therapy options for patients with advanced angiosarcomas are limited, and their prognosis is poor. The idea of angiostatic therapy following the paradigm of metronomic dosed chemotherapeutics combined with proapoptotic biomodulators had not been considered previously in these patients. Therefore, in a pilot study, the efficacy of metronomically scheduled, low-dose ...
Zusammenfassung
BACKGROUND. Systemic therapy options for patients with advanced angiosarcomas are limited, and their prognosis is poor. The idea of angiostatic therapy following the paradigm of metronomic dosed chemotherapeutics combined with proapoptotic biomodulators had not been considered previously in these patients. Therefore, in a pilot study, the efficacy of metronomically scheduled, low-dose trofosfamide in combination with the peroxisome proliferator-activated receptor gamma agonist, pioglitazone, and the selective cyclooxygenase-2 inhibitor, rofecoxib, was evaluated in patients with advanced vascular malignancies. METHODS. Six patients with advanced and pretreated but progressive, malignant vascular tumors (5 angiosarcomas and 1 hemangioendothelioma) received a combination of pioglitazone (45 mg per day orally) plus rofecoxib (25 mg per day orally) and, after 14 days, trofosfamide (3 X 50 mg per day orally). The therapy was administered continuously until progression was observed. If necessary, doses were modified according to side effects. RESULTS. Two patients responded with complete remission of disease, one patient responded with partial remission, and three patients achieved stabilization of disease (no change). The median progression-free survival was 7.7 months (range, 2-15 months). Side effects generally were mild (World Health Organization Grade 1-2). Hospitalization was not necessary. CONCLUSIONS. This new triple combination of low-dose metronomic trofosfamide, pioglitazone, and rofecoxib may represent a feasible new alternative in the palliative treatment of patients with advanced malignant vascular tumors. (C) 2003 American Cancer Society.
Metadaten zuletzt geändert: 29 Sep 2021 07:37
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