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Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation

Gerbitz, Armin ; Ewing, Patricia ; Wilke, Andrea ; Schubert, Thomas ; Eissner, Günther ; Dietl, Barbara ; Andreesen, Reinhard ; Cooke, Kenneth R. ; Holler, Ernst



Abstract

Acute graft-versus-host disease (aGVHD) remains one of the main obstacles after allogeneic bone marrow transplantation (BMT). Using a well-established mouse BMT model in which aGVHD is induced across a haploidentical mismatch, we show that the expression of heme oxygenase-1 (HO-1) can be induced by cobalt-protoporphyrin IX (CoPP) in aGVHD target organs such as liver and bowel and that the ...

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