| Item type: | Article | ||||||||||||||||||||||||||||||||||||||
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| Journal or Publication Title: | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation | ||||||||||||||||||||||||||||||||||||||
| Publisher: | CARDEN JENNINGS PUBL CO LTD | ||||||||||||||||||||||||||||||||||||||
| Place of Publication: | CHARLOTTESVILLE | ||||||||||||||||||||||||||||||||||||||
| Volume: | 10 | ||||||||||||||||||||||||||||||||||||||
| Number of Issue or Book Chapter: | 7 | ||||||||||||||||||||||||||||||||||||||
| Page Range: | pp. 461-72 | ||||||||||||||||||||||||||||||||||||||
| Date: | 2004 | ||||||||||||||||||||||||||||||||||||||
| Institutions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Strahlentherapie | ||||||||||||||||||||||||||||||||||||||
| Identification Number: |
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| Classification: |
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| Keywords: | NECROSIS-FACTOR-ALPHA; T-REGULATORY-CELLS/; CYTOKINE DYSREGULATION; IL-10 PRODUCTION; LUNG INJURY; MICE; INTERLEUKIN-10; COMPLICATIONS; EXPRESSION; MODULATION; GVHD e; cytokines; heme oxygenase; BMT; LPS; protoporphyrin; CoPP | ||||||||||||||||||||||||||||||||||||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||||||||||||||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||||||||||||||||
| Refereed: | Yes, this version has been refereed | ||||||||||||||||||||||||||||||||||||||
| Created at the University of Regensburg: | Yes | ||||||||||||||||||||||||||||||||||||||
| Item ID: | 14425 |
Web of ScienceAbstract
Acute graft-versus-host disease (aGVHD) remains one of the main obstacles after allogeneic bone marrow transplantation (BMT). Using a well-established mouse BMT model in which aGVHD is induced across a haploidentical mismatch, we show that the expression of heme oxygenase-1 (HO-1) can be induced by cobalt-protoporphyrin IX (CoPP) in aGVHD target organs such as liver and bowel and that the ...
Abstract
Acute graft-versus-host disease (aGVHD) remains one of the main obstacles after allogeneic bone marrow transplantation (BMT). Using a well-established mouse BMT model in which aGVHD is induced across a haploidentical mismatch, we show that the expression of heme oxygenase-1 (HO-1) can be induced by cobalt-protoporphyrin IX (CoPP) in aGVHD target organs such as liver and bowel and that the induction of HO-1 before BMT results in improved overall survival and reduced aGVHD. Serum levels of proinflammatory cytokines were markedly reduced in CoPP-treated animals. Recipients displayed less damage to the intestinal mucosa, and this resulted in reduced serum lipopolysaccharide levels at day 6 after transplantation. Peritoneal cells and CD45(+) liver cells isolated from mice that received transplants strongly expressed HO-1 and displayed a reduction in the expression of activation markers such as CD11b, CD80, and major histocompatibility complex class I. This resulted in reduced T-cell activation ex vivo. These results demonstrate that the induction of HO-1 before high-dose conditioning protects the host in multiple ways and effectively ameliorates aGVHD. (C) 2004 American Society for Blood and Marrow Transplantationy.
Metadata last modified: 29 Sep 2021 07:37
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