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Impact of thrombophilic gene mutations and graft-versus-host disease on thromboembolic complications after allogeneic hematopoietic stem-cell transplantation

Pihusch, Markus ; Lohse, Peter ; Reitberger, Jill ; Hiller, Erhard ; Andreesen, Reinhard ; Kolb, Hans-Jochem ; Holler, Ernst ; Pihusch, Rudolf


BACKGROUND: Hemostatic events in patients undergoing allogeneic hematopoietic stem-cell transplantation (HSCT) increase the morbidity and mortality in this cohort. Little is known about the impact of graft-versus-host disease (GvHD) or of thrombophilic gene mutations/polymorphisms on these complications. STUDY DESIGN: Eighty-nine allogeneic stem-cell recipients and their donors were evaluated ...


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