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Inhibitory effect of tumor cell-derived lactic acid on human T cells

Fischer, Karin ; Hoffmann, Petra ; Voelkl, Simon ; Meidenbauer, Norbert ; Ammer, Julia ; Edinger, Matthias ; Gottfried, Eva ; Schwarz, Sabine ; Rothe, Gregor ; Hoves, Sabine ; Renner, Kathrin ; Timischl, Birgit ; Mackensen, Andreas ; Kunz-Schughart, Leoni ; Andreesen, Reinhard ; Krause, Stefan W. ; Kreutz, Marina



Abstract

A characteristic feature of tumors is high production of lactic acid due to enhanced glycolysis. Here, we show a positive correlation between lactate serum levels and tumor burden in cancer patients and examine the influence of lactic acid on immune functions in vitro. Lactic acid suppressed the proliferation and cytokine production of human cytotoxic T lymphocytes (CTLs) up to 95% and led to a ...

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