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FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours

van Oers, Johanna M. M., Wild, Peter J., Burger, Maximilian, Denzinger, Stefan, Stoehr, Robert, Rosskopf, Elke, Hofstaedter, Ferdinand, Steyerberg, Ewout W., Klinkhammer-Schalke, Monika, Zwarthoff, Ellen C., van der Kwast, Theodorus H. and Hartmann, Arndt (2007) FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. European urology 52 (3), pp. 760-768.

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Abstract

OBJECTIVES: Molecular markers superior to conventional clinicopathologic parameters are needed to predict disease courses in bladder cancer patients. In this study, we investigated four markers (Ki-67, TP53, CK20, FGFR3) in primary urothelial bladder tumours and compared them with traditional pathologic features. METHODS: Tissue microarrays were used to analyse CK20, TP53, and Ki-67 expression ...

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Item type:Article
Date:2007
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
17240042PubMed ID
10.1016/j.eururo.2007.01.009DOI
Classification:
NotationType
AgedMESH
Carcinoma, Papillary/pathologyMESH
DNA, Neoplasm/geneticsMESH
FemaleMESH
Follow-Up StudiesMESH
Gene Expression Regulation, NeoplasticMESH
HumansMESH
ImmunohistochemistryMESH
Keratin-20/metabolismMESH
Ki-67 Antigen/metabolismMESH
MaleMESH
MutationMESH
Neoplasm StagingMESH
Polymerase Chain ReactionMESH
Receptor, Fibroblast Growth Factor, Type 3/metabolismMESH
Retrospective StudiesMESH
Time FactorsMESH
Tumor Markers, Biological/metabolismMESH
Tumor Suppressor Protein p53/metabolismMESH
Urinary Bladder Neoplasms/pathologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Item ID:14596
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