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FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours

van Oers, Johanna M. M. ; Wild, Peter J. ; Burger, Maximilian ; Denzinger, Stefan ; Stoehr, Robert ; Rosskopf, Elke ; Hofstaedter, Ferdinand ; Steyerberg, Ewout W. ; Klinkhammer-Schalke, Monika ; Zwarthoff, Ellen C. ; van der Kwast, Theodorus H. ; Hartmann, Arndt



Abstract

OBJECTIVES: Molecular markers superior to conventional clinicopathologic parameters are needed to predict disease courses in bladder cancer patients. In this study, we investigated four markers (Ki-67, TP53, CK20, FGFR3) in primary urothelial bladder tumours and compared them with traditional pathologic features. METHODS: Tissue microarrays were used to analyse CK20, TP53, and Ki-67 expression ...

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