Monoclonal antibodies to common epitopes of the human alpha/beta T-cell receptor preferentially activate CD45RA+ T-cells

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.14718

Schwinzer, Reinhard ; Schlitt, Hans-Jürgen ; Wonigeit, Kurt

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Veröffentlichungsdatum dieses Volltextes: 10 Mai 2010 12:17

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Zusammenfassung

The murine monoclonal antibody BMA 031 (IgG2b) is directed to a monomorphic epitope on the human alpha/beta T-cell receptor. In contrast to anti-CD3 antibodies of the IgG2b isotype, BMA 031 is able to induce a proliferative response in T-cells from IgG2b low responders. This response occurs independently of cross-linking conditions indicating that the mode of activation differs from stimulation ...