Activation of human thymocytes by antibodies to the CD3/T-cell receptor complex: triggering of different epitopes results in different signals

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.14723

Schwinzer, R. ; Sommermeyer, H. ; Schlitt, Hans-Jürgen ; Schmidt, R. E. ; Wonigeit, K.

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Veröffentlichungsdatum dieses Volltextes: 10 Mai 2010 12:20

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Zusammenfassung

Monoclonal antibodies (mAb) against the CD3/T cell receptor (TcR) complex were analyzed for their ability to activate human thymocytes. In addition to mAb detecting epitopes on the CD3 complex (OKT3, BMA 030) the activation potential of recently developed mAb against common epitopes on the alpha/beta T-cell receptor (anti-TcR mAb: BMA 031, BMA 032) was evaluated. Several differences were observed ...