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Activation of human thymocytes by antibodies to the CD3/T-cell receptor complex: triggering of different epitopes results in different signals

DOI to cite this document:
Schwinzer, R. ; Sommermeyer, H. ; Schlitt, Hans-Jürgen ; Schmidt, R. E. ; Wonigeit, K.
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Date of publication of this fulltext: 10 May 2010 12:20


Monoclonal antibodies (mAb) against the CD3/T cell receptor (TcR) complex were analyzed for their ability to activate human thymocytes. In addition to mAb detecting epitopes on the CD3 complex (OKT3, BMA 030) the activation potential of recently developed mAb against common epitopes on the alpha/beta T-cell receptor (anti-TcR mAb: BMA 031, BMA 032) was evaluated. Several differences were observed ...


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