Effect of N,N'-diethyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines on the DMBA-induced mammary carcinoma of the rat

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.14970

Angerer, Erwin von

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Veröffentlichungsdatum dieses Volltextes: 17 Mai 2010 12:14

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Zusammenfassung

The syntheses and estrogen receptor affinities of meso- and (~)-N,N’-dialkyl-1,2-bis(2,6-dichloro-4-hydroxypheny1) ethylenediamines (2) are described. They show high binding affinities in both diastereomeric forms but with a preference for the meso isomer, reaching a RBA value of 8.6 (meso-2b; 17@-estradiol=1 00). Both stereoisomers of 2b exhibit a strong inhibitory effect on the ...