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Computational and Experimental Evidence for the Evolution of a (betaalpha)(8)-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds

Richter, Markus ; Bosnali, Manal ; Carstensen, Linn ; Seitz, Tobias ; Durchschlag, Helmut ; Blanquart, Samuel ; Merkl, Rainer ; Sterner, Reinhard


The evolution of the prototypical (beta alpha)(8)-barrel protein imidazole glycerol phosphate synthase (HisF) was studied by complementary computational and experimental approaches. The 4-fold symmetry of HisF suggested that its constituting (beta alpha)(2) quarter-barrels have a common evolutionary origin. This conclusion was supported by the computational reconstruction of the HisF sequence of ...


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