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Reduced deposition of aluminium in trabecular bone of uraemic rats treated with dihydroxylated vitamin D metabolites

Ittel, T. H. ; Hofstädter, Ferdinand ; Gladziwa, U. ; Sieberth, H. G.


The rate of aluminium accumulation in bone may be related to the presence of vitamin D metabolites. The present study investigated the effect of 1,25(OH)2D3 (24 pmol/d s.c.) and 24R,25(OH)2D3 (480 pmol/day), combined or alone, on the deposition of aluminium (119 mumol/kg per day) in bone of uraemic rats during concomitant parenteral administration of aluminium for 9 weeks. Bone histomorphometry ...


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