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New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies

Höcherl, Peter (2010) New tariquidar-like ABCB1 modulators in cancer chemotherapy:
Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies.
PhD, Universität Regensburg.

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Date of publication of this fulltext: 19 Jul 2010 09:35

Abstract (English)

The ABCB1 transporter (P-glycoprotein), an ATP-driven efflux protein, strongly influences the absorption, distribution and excretion of various drugs. As an essential component of the blood-brain barrier, P-glycoprotein limits the penetration of potent cytostatic agents (e.g. paclitaxel) into the central nervous system (CNS). Furthermore, over-expression of ABCB1 transporters in tumor cells is ...

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Translation of the abstract (German)

Der ABCB1-Transporter (P-glycoprotein), eine ATP-abhängige Efflux-Pumpe, beeinflusst die Absorption, Verteilung und Ausscheidung verschiedenster Arzneistoffe und verhindert als wesentlicher Bestandteil der Blut-Hirn-Schranke den Übertritt wirksamer Zytostatika (z.B. Paclitaxel) in das Zentralnervensystem (ZNS). Darüber hinaus führt die Überexpression von ABCB1 in Krebszellen zur ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:19 July 2010
Referee:Prof. Dr. Armin Buschauer and Prof. Dr. Günther Bernhardt
Date of exam:2 June 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Interdisciplinary Subject Network:Not selected
Keywords:ABC transporter, P-glycoprotein, tariquidar, brain tumors, glioblastoma, blood-brain barrier, paclitaxel, MDR, Paclitaxel, optical imaging
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:15219
Owner only: item control page

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