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Characterization of the new bladder cancer cell line HOK-1: expression of transitional, squamous and glandular differentiation patterns

Offner, F. A. ; Ott, G. ; Povey, S. ; Knuechel, R. ; Preisler, V. ; Fuezesi, L. ; Klosterhalfen, B. ; Ruebben, H. ; Hofstaedter, Ferdinand ; Kirkpatrick, C. J.


The new continuous cell line HOK-1 derived from a grade-III transitional-cell bladder carcinoma with foci of squamous and glandular differentiation was shown to retain this phenotypical heterogeneity for more than 45 passages in vitro. Electron microscopy revealed transitional as well as a considerable proportion of squamous carcinoma and adenocarcinoma cells. PAS-positive mucus was detected in ...


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