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Comparative genomic in situ hybridization of colon carcinomas with replication error

Schlegel, J. ; Stumm, G ; Scherthan, H. ; Bocker, T. ; Zirngibl, H. ; Rüschoff, J. ; Hofstädter, Ferdinand


The aim of the present study was to detect complex genetic alterations in colorectal carcinomas with and without microsatellite instability (MIN) by comparative genomic in situ hybridization. MIN due to replication errors is the hallmark of hereditary nonpolyposis colon cancer. None of 6 MIN-positive tumors showed amplifications, and only 2 tumors displayed deletions of one chromosomal segment ...


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