A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis

Michel, J., Langstein, J., Hofstädter, Ferdinand and Schwarz, H. (1998) A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. European journal of immunology 28 (1), pp. 290-295.

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Abstract

CD137 (ILA/4-1BB) is a member of the tumor necrosis factor receptor family and regulates activation, proliferation and programmed cell death in T lymphocytes. Here we show the existence of a soluble form of CD137 (sCD137) of 16 kDa. sCD137 is released by activated lymphocytes, and in contrast to membrane-bound CD137, expression of sCD137 seems to be restricted to lymphocytes. sCD137 is generated ...

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Item type:

Article

Date:

1998

Institutions:

Medicine > Lehrstuhl für Pathologie

Identification Number:

Value	Type
9485208	PubMed ID
10.1002/(SICI)1521-4141(199801)28:01<290::AID-IMMU290>3.0.CO;2-S	DOI

Classification:

Notation	Type
Antigens, CD	MESH
Antigens, CD137	MESH
Arthritis, Rheumatoid/blood	MESH
Enzyme-Linked Immunosorbent Assay	MESH
Humans	MESH
Lymphocyte Activation	MESH
Lymphocytes/secretion	MESH
Polymerase Chain Reaction	MESH
RNA Splicing	MESH
Receptors, Nerve Growth Factor/genetics	MESH
Receptors, Tumor Necrosis Factor/genetics	MESH
Solubility	MESH
Tumor Cells, Cultured	MESH