Michel, J. ; Langstein, J. ; Hofstädter, Ferdinand ; Schwarz, H.
Alternative Links zum Volltext:PubmedDOI
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | European journal of immunology |
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| Verlag: | Wiley-VCH |
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| Band: | 28 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 |
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| Seitenbereich: | S. 290-295 |
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| Datum: | 1998 |
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| Institutionen: | Medizin > Lehrstuhl für Pathologie |
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| Identifikationsnummer: | | Wert | Typ |
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| 9485208 | PubMed-ID | | 10.1002/(SICI)1521-4141(199801)28:01<290::AID-IMMU290>3.0.CO;2-S | DOI |
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| Klassifikation: | | Notation | Art |
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| Antigens, CD | MESH | | Antigens, CD137 | MESH | | Arthritis, Rheumatoid/blood | MESH | | Enzyme-Linked Immunosorbent Assay | MESH | | Humans | MESH | | Lymphocyte Activation | MESH | | Lymphocytes/secretion | MESH | | Polymerase Chain Reaction | MESH | | RNA Splicing | MESH | | Receptors, Nerve Growth Factor/genetics | MESH | | Receptors, Tumor Necrosis Factor/genetics | MESH | | Solubility | MESH | | Tumor Cells, Cultured | MESH |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Unbekannt / Keine Angabe |
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| An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe |
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| Dokumenten-ID: | 15346 |
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Zusammenfassung
CD137 (ILA/4-1BB) is a member of the tumor necrosis factor receptor family and regulates activation, proliferation and programmed cell death in T lymphocytes. Here we show the existence of a soluble form of CD137 (sCD137) of 16 kDa. sCD137 is released by activated lymphocytes, and in contrast to membrane-bound CD137, expression of sCD137 seems to be restricted to lymphocytes. sCD137 is generated ...
Zusammenfassung
CD137 (ILA/4-1BB) is a member of the tumor necrosis factor receptor family and regulates activation, proliferation and programmed cell death in T lymphocytes. Here we show the existence of a soluble form of CD137 (sCD137) of 16 kDa. sCD137 is released by activated lymphocytes, and in contrast to membrane-bound CD137, expression of sCD137 seems to be restricted to lymphocytes. sCD137 is generated by alternative splicing and two splice variants were identified. sCD137 is present at low levels in sera of some healthy donors (5/12; mean = 0.18 ng/ml) and is significantly enhanced in sera of patients with rheumatoid arthritis (12/12; mean = 3.58 ng/ml).
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