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Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer

Stoehr, Robert, Wissmann, Christoph, Suzuki, Hiromu, Knuechel, Ruth, Krieg, Rene C., Klopocki, Eva, Dahl, Edgar, Wild, Peter, Blaszyk, Hagen, Sauter, Guido, Simon, Ronald, Schmitt, Ruediger, Zaak, Dirk, Hofstaedter, Ferdinand, Rosenthal, Andre, Baylin, Stephen B., Pilarsky, Christian and Hartmann, Arndt (2004) Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer. Laboratory investigation 84 (4), pp. 465-478.

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Many molecular alterations are known to occur in urothelial carcinoma of the bladder, but their significance for tumor progression is poorly understood. Deletions of chromosome 8p are frequently found in several tumor types and are often associated with progressive disease. In all, 99 bladder tumors were screened for deletions at 8p using loss of heterozygosity (LOH) and multicolor fluorescence ...


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Item type:Article
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
14968126PubMed ID
Blotting, NorthernMESH
Cell Line, TumorMESH
Chromosome DeletionMESH
Chromosomes, Human, Pair 8MESH
DNA MethylationMESH
Disease ProgressionMESH
In Situ Hybridization, FluorescenceMESH
Intercellular Signaling Peptides and Proteins/geneticsMESH
Loss of HeterozygosityMESH
Membrane Proteins/geneticsMESH
Promoter Regions, GeneticMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Tumor Markers, BiologicalMESH
Urinary Bladder Neoplasms/geneticsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Created at the University of Regensburg:Unknown
Item ID:15418
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