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Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer

Stoehr, Robert ; Wissmann, Christoph ; Suzuki, Hiromu ; Knuechel, Ruth ; Krieg, Rene C. ; Klopocki, Eva ; Dahl, Edgar ; Wild, Peter ; Blaszyk, Hagen ; Sauter, Guido ; Simon, Ronald ; Schmitt, Ruediger ; Zaak, Dirk ; Hofstaedter, Ferdinand ; Rosenthal, Andre ; Baylin, Stephen B. ; Pilarsky, Christian ; Hartmann, Arndt


Many molecular alterations are known to occur in urothelial carcinoma of the bladder, but their significance for tumor progression is poorly understood. Deletions of chromosome 8p are frequently found in several tumor types and are often associated with progressive disease. In all, 99 bladder tumors were screened for deletions at 8p using loss of heterozygosity (LOH) and multicolor fluorescence ...


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