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Properties of the human umbilical vein as a living scaffold for a tissue-engineered vessel graft.

Hoenicka, Markus ; Lehle, Karla ; Jacobs, Volker R. ; Schmid, Franz X. ; Birnbaum, Dietrich E.


Umbilical cords are usually discarded after delivery, even though they contain a set of functional vessels. We investigated whether the human umbilical vein (HUV) is suitable as a storable scaffold for the tissue engineering of small-caliber vessel grafts. Isolated HUVs were cryopreserved by freezing or vitrification. The reaction of the vessels to vasoactive compounds and the mechanical ...


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