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Dithranol, Active Oxygen Species and Lipid Peroxidation in vivo

Müller, K., Wiegrebe, Wolfgang and Younes, Maged (1987) Dithranol, Active Oxygen Species and Lipid Peroxidation in vivo. Archiv der Pharmazie 320, pp. 59-66.

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Date of publication of this fulltext: 07 Jul 2010 05:05


At pH 7.8 the dithranol anion 1a is oxidized in the dark to yield the bianthrone 3 besides dithranol brown, whilst 02 is reduced to 02.- and H202. 02.- was detected by the reduction of nitroblue-tetrazolium (NBT, 4). The formation of the formazan 5 was inhibited by superoxide dismutase (SOD). Exclusion of 02 and addition of SOD reveal a direct electron transfer from 1a to 4 and to cytochrome c ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:15666
Owner only: item control page


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