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Dithranol, Active Oxygen Species and Lipid Peroxidation in vivo

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Müller, K. ; Wiegrebe, Wolfgang ; Younes, Maged
Date of publication of this fulltext: 07 Jul 2010 05:05


At pH 7.8 the dithranol anion 1a is oxidized in the dark to yield the bianthrone 3 besides dithranol brown, whilst 02 is reduced to 02.- and H202. 02.- was detected by the reduction of nitroblue-tetrazolium (NBT, 4). The formation of the formazan 5 was inhibited by superoxide dismutase (SOD). Exclusion of 02 and addition of SOD reveal a direct electron transfer from 1a to 4 and to cytochrome c ...


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