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Synthesis and Antitumor Activity of Methoxy-indolo[2,1-a]isoquinolines

URN to cite this document:
urn:nbn:de:bvb:355-epub-156954
Ambros, R. ; Angerer, S. von ; Wiegrebe, Wolfgang
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Date of publication of this fulltext: 07 Jul 2010 05:15


Abstract

Methoxy-indolo[2,1-a]isoquinolines 8a-f and their dihydroderivatives 7a-f were synthesized by Bischler-Napieralski reaction of the (bromomethoxyphenyl)-[ 2-(methoxyphenyl)-ethyl]acetamides 4a-f, reduction, subsequent cyclization and dehydrogenation. They were tested for cytostatic activity in vitro using P388 D1 leukemia and MDA MB 231 mammary tumor cells. The ...

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