Go to content
UR Home

C-12-Substituted Indolo [2,1-a]isoquinolines as Estrogen Receptor Affinic Cytostatic Agents

URN to cite this document:
urn:nbn:de:bvb:355-epub-156968
Ambros, R. ; Angerer, S. von ; Wiegrebe, Wolfgang
[img]
Preview
PDF
(1MB)
Date of publication of this fulltext: 07 Jul 2010 05:15


Abstract

Methoxysubstituted 5,6-dihydro-indolo[2,1-a]isoquinolines with a methyl (2b-f) or a formyl group at C-12 (4a-f) and 12,12-dimethylisoquinolinium salts (3b-f) were synthesized and tested for cytostatic activity in vitro. The tetramethoxy-indoloisoquinoline 4f was the most active derivative in the P 388 D1 leukemia cell line, whereas compounds with two methoxy groups (4a, 4b) were more potent ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons