Anthralin Derivatives - Inhibition of 5-Lipoxygenase - Antipsoriatic Efficacy - University of Regensburg Publication Server

URN to cite this document:: urn:nbn:de:bvb:355-epub-157319
DOI to cite this document:: 10.5283/epub.15731

Tanzer, H. ; Braun, C. ; Seidel, M. ; Wiegrebe, Wolfgang

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Date of publication of this fulltext: 08 Jul 2010 05:09

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Item type:	Article
Journal or Publication Title:	Archiv der Pharmazie
Publisher:	John Wiley & Sons
Volume:	324
Page Range:	pp. 841-846
Date:	1991
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Dewey Decimal Classification:	500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	15731

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Abstract

Inhibition of 5-lipoxygenase by anthralin (1) and 41 derivatives is determined: the acids 38 and 39, the lactones 40-42 and 9-anthrone (8) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no ...

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Anthralin Derivatives - Inhibition of 5-Lipoxygenase - Antipsoriatic Efficacy

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