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Anthralin Derivatives - Inhibition of 5-Lipoxygenase - Antipsoriatic Efficacy

URN to cite this document:
urn:nbn:de:bvb:355-epub-157319
Tanzer, H. ; Braun, C. ; Seidel, M. ; Wiegrebe, Wolfgang
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Date of publication of this fulltext: 08 Jul 2010 05:09


Abstract

Inhibition of 5-lipoxygenase by anthralin (1) and 41 derivatives is determined: the acids 38 and 39, the lactones 40-42 and 9-anthrone (8) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no ...

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