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O-Methylating Enzymes of Dopamine and Dopamine Derived Tetrahydroisoquinoline, Salsolinol

URN to cite this document:
urn:nbn:de:bvb:355-epub-157828
Iwasa, K. ; Kamigauchi, M. ; Saiki, K. ; Takao, N. ; Wiegrebe, Wolfgang
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Date of publication of this fulltext: 12 Jul 2010 07:52


Abstract

By using an LC/API-MS system, it was demonstrated that dopamine condenses with acetaldehyde to give salsolinol which is further metabolized to produce 6-O-methylsalsolinol (isosalsoline) which is O- and N-methylated to provide salsolidine and N-methylisosalsoline, respectively, in several plant tissue cultures of Papaveraceae. Almost none of the 3-O-methoxytyramine formed from dopamine was ...

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