O-Methylating Enzymes of Dopamine and Dopamine Derived Tetrahydroisoquinoline, Salsolinol

URN to cite this document:: urn:nbn:de:bvb:355-epub-157828
DOI to cite this document:: 10.5283/epub.15782

Iwasa, K. ; Kamigauchi, M. ; Saiki, K. ; Takao, N. ; Wiegrebe, Wolfgang

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Date of publication of this fulltext: 12 Jul 2010 07:52

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Item type:	Article
Journal or Publication Title:	Phytochemistry
Publisher:	Elsevier
Volume:	32
Page Range:	pp. 1443-1448
Date:	1993
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Keywords:	Corydalis pallida var. tenuis, C. ochotensis var. raddeana, C. incisa; Macleaya cordata; Papaveraceae; Cynanchum vincetoxicum; Asclepiadaceae; dopamine; isoquinoline alkaloids; tissue cultures; metabolism
Dewey Decimal Classification:	500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	15782

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Abstract

By using an LC/API-MS system, it was demonstrated that dopamine condenses with acetaldehyde to give salsolinol which is further metabolized to produce 6-O-methylsalsolinol (isosalsoline) which is O- and N-methylated to provide salsolidine and N-methylisosalsoline, respectively, in several plant tissue cultures of Papaveraceae. Almost none of the 3-O-methoxytyramine formed from dopamine was ...