Effects of Shear Forces and Pressure on Blood Vessel Function and Metabolism in a Perfusion Bioreactor.

URN to cite this document:: urn:nbn:de:bvb:355-epub-158844
DOI to cite this document:: 10.5283/epub.15884

Hoenicka, Markus ; Wiedemann, Ludwig ; Puehler, Thomas ; Hirt, Stephan ; Birnbaum, Dietrich E. ; Schmid, Christof

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Date of publication of this fulltext: 15 Jul 2010 09:33

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Abstract

Bovine saphenous veins (BSV) were incubated in a perfusion bioreactor to study vessel wall metabolism and wall structure under tissue engineering conditions. Group 1 vessels were perfused for 4 or 8 days. The viscosity of the medium was increased to that of blood in group 2. Group 3 vessels were additionally strained with luminal pressure. Groups 1-d through 3-d were similar except that BSV were ...