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DNA-Interaction, Estrogen Receptor Affinity, and Cytostatic Activity of 1,3-Diphenylpropane-1,3-diamine-Pt(II) Complexes

Kammermeier, T. ; Wiegrebe, Wolfgang



Abstract

The Pt(II) complexes of 1,3-diphenylpropane-1,3-diamines (part IV 2)) were tested for DNA interaction (UV-difference spectroscopy, Tables 1 and 2), for affinity to the estrogen receptor (calf uterus cytosol; scarcely any affinity), and for cytostatic activity at estrogen independent MDA-MB 231 cells (Tables 3 and 4) and estrogen dependent MCF-7 cells (Tables 5 and 6). The data are compared with ...

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