Interferon gamma and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of Schistosoma mansoni

URN to cite this document:: urn:nbn:de:bvb:355-epub-159863
DOI to cite this document:: 10.5283/epub.15986

Esparza, I. ; Männel, Daniela N. ; Ruppel, A. ; Falk, Werner ; Krammer, P. H.

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Date of publication of this fulltext: 22 Jul 2010 05:09

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Abstract

Macrophages play a crucial role in the defense against tumors and parasites. Activation of tumoricidal and microbicidal effector mechanisms requires stimulation of macrophages with macrophage-activating factors (MAF). One such MAF is interferon gamma (IFN-gamma). In some assays, substantial activity of IFN-gamma on murine macrophages, however, is only observed in synergy with lipopolysaccharide ...