Endotoxic activities of tumor necrosis factor independent of IL1 secretion by macrophages/monocytes

URN to cite this document:: urn:nbn:de:bvb:355-epub-159896
DOI to cite this document:: 10.5283/epub.15989

Männel, D. N. ; Falk, Werner ; Northoff, H.

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Date of publication of this fulltext: 21 Jul 2010 09:19

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Abstract

Recombinant tumor necrosis factor (TNF) had hypothermic activity in vivo. Intravenous injection of TNF resulted in a hypothermic reaction of mice within 3 to 6 hours. This reaction was not the result of interleukin 1 (IL1) release from macrophages/monocytes. Peritoneal exudate cell cultures from endotoxin low responder mice or human peripheral mononuclear leukocyte cultures did not generate IL1 ...