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Endotoxic activities of tumor necrosis factor independent of IL1 secretion by macrophages/monocytes

URN to cite this document:
Männel, D.N. ; Falk, Werner ; Northoff, H.
Date of publication of this fulltext: 21 Jul 2010 09:19


Recombinant tumor necrosis factor (TNF) had hypothermic activity in vivo. Intravenous injection of TNF resulted in a hypothermic reaction of mice within 3 to 6 hours. This reaction was not the result of interleukin 1 (IL1) release from macrophages/monocytes. Peritoneal exudate cell cultures from endotoxin low responder mice or human peripheral mononuclear leukocyte cultures did not generate IL1 ...


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